The Role of Exercise and PGC1alpha in Inflammation and Chronic Disease

Nature. 2008 Jul 24;454(7203):463-9. doi: 10.1038/nature07206.

Abstract

Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1alpha has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chronic Disease
  • Exercise / physiology*
  • Humans
  • Inflammation / genetics
  • Inflammation / metabolism*
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / physiology
  • Obesity / genetics
  • Obesity / immunology
  • Obesity / physiopathology
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • Transcription Factors
  • peroxisome-proliferator-activated receptor-gamma coactivator-1