[Sdudy on effect of tripterygium on plasma IL-18 content in patients with lupus nephritis]

Zhongguo Zhong Yao Za Zhi. 2008 May;33(9):1075-7.
[Article in Chinese]


Objective: It is to study the effect of tripterygium (TW) on the plasma IL-18 content in patients with lupus nephritis (LN) and its treatment value.

Method: The patients with LN treated with prednisone were divided into active groupand inactive group with active index. The active group was given tripterygium additionally. The changing of plasma IL-18 and release of nephritis were observed after treatment for three months.

Result: The level of plasma IL-18 lowered down obviously, urinary protein decreased, LN activity index, hematuria and renal function improved.

Conclusion: Tripterygium caninhibitroduction of plasma IL-18. It has definite treatment value on controlling LN activity.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Drugs, Chinese Herbal / adverse effects
  • Drugs, Chinese Herbal / therapeutic use*
  • Female
  • Humans
  • Interleukin-18 / blood*
  • Lupus Nephritis / blood*
  • Lupus Nephritis / drug therapy*
  • Male
  • Middle Aged
  • Retrospective Studies
  • Treatment Outcome
  • Tripterygium / chemistry*
  • Young Adult


  • Drugs, Chinese Herbal
  • Interleukin-18