JAZ Repressors Set the Rhythm in Jasmonate Signaling

Curr Opin Plant Biol. 2008 Oct;11(5):486-94. doi: 10.1016/j.pbi.2008.06.003. Epub 2008 Jul 22.

Abstract

Jasmonates (JAs) are essential hormones for plant defense and development. In spite of their importance, the molecular details of their signaling pathways remain largely unknown. A new family of regulators of JA signaling named JAZ, jasmonate ZIM-domain proteins, has recently been described. JAZ proteins repress of JA signaling and are targeted by the E3-ubiquitin ligase SCF(COI1) for proteasome degradation in response to JA. Hormone binding depends on a functional COI1 protein suggesting that COI1 is the JA receptor. MYC2, a positive regulator of JA-dependent responses, has been identified as a target of JAZ repressors. Interestingly, MYC2 and JAZ proteins are involved in a negative regulatory feedback loop, suggesting a model to explain how transcriptional reprogramming is turned on and off in response to JA. The discovery of JAZ repressors provides a new framework to understand JA-signaling pathways from hormonal perception to transcriptional activation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Motifs
  • Arabidopsis Proteins / chemistry
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism
  • Arabidopsis Proteins / physiology*
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism
  • Cyclopentanes / metabolism*
  • Feedback, Physiological
  • Models, Biological
  • Multigene Family
  • Oxylipins / metabolism*
  • Phylogeny
  • Proteasome Endopeptidase Complex / metabolism
  • Repressor Proteins / chemistry
  • Repressor Proteins / genetics
  • Repressor Proteins / physiology*
  • SKP Cullin F-Box Protein Ligases / metabolism
  • SKP Cullin F-Box Protein Ligases / physiology
  • Signal Transduction / physiology*

Substances

  • Arabidopsis Proteins
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • COI1 protein, Arabidopsis
  • Cyclopentanes
  • MYC2 protein, Arabidopsis
  • Oxylipins
  • Repressor Proteins
  • jasmonic acid
  • SKP Cullin F-Box Protein Ligases
  • Proteasome Endopeptidase Complex