Immunoregulatory effects of ovine trophoblastin protein (oTP): all five isoforms suppress PHA-induced lymphocyte proliferation

C Fillion; G Chaouat; P Reinaud; J C Charpigny; J Martal

doi:10.1016/0165-0378(91)90038-r

Immunoregulatory effects of ovine trophoblastin protein (oTP): all five isoforms suppress PHA-induced lymphocyte proliferation

J Reprod Immunol. 1991 Apr;19(3):237-49. doi: 10.1016/0165-0378(91)90038-r.

Authors

C Fillion¹, G Chaouat, P Reinaud, J C Charpigny, J Martal

Affiliation

¹ U 262 INSERM, Maternité de Baudelocque, Paris, France.

PMID: 1865389
DOI: 10.1016/0165-0378(91)90038-r

Abstract

The immunosuppressive properties of ovine trophoblastin protein (oTP) isoforms purified to homogeneity by DEAE HPLC have been studied within and across species barriers by in vitro assays. It has been demonstrated that not only the classical oTP 1, but in fact all 5 isoforms, are immunosuppressive in a PHA-induced proliferation assay, whilst being ineffective on IL-2 dependent CTL-L2 cell replication. The significance of these findings is discussed.

MeSH terms

Animals
Culture Media
Culture Techniques
Goats / blood
Humans
Immunosuppressive Agents / pharmacology*
Interferon Type I*
Interleukin-2 / pharmacology
Lymphocyte Activation / drug effects*
Phytohemagglutinins / antagonists & inhibitors
Phytohemagglutinins / pharmacology
Pregnancy Proteins / isolation & purification
Pregnancy Proteins / pharmacology*
Sheep / embryology
T-Lymphocyte Subsets / drug effects*

Substances

Culture Media
Immunosuppressive Agents
Interferon Type I
Interleukin-2
Phytohemagglutinins
Pregnancy Proteins
interferon tau