Stawamycin analog, JBIR-11 from Streptomyces viridochromogenes subsp. sulfomycini NBRC 13830

J Antibiot (Tokyo). 2008 May;61(5):326-9. doi: 10.1038/ja.2008.47.

Abstract

A stawamycin analog, JBIR-11 (1) was isolated from mycelium of Streptomyces viridochromogenes subsp. sulfomycini NBRC 13830. The structure was determined on the basis of the spectroscopic data. Compound 1 exhibited growth inhibitory effect against human fibrosarcoma HT1080 cells with an IC50 value of 25 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antineoplastic / biosynthesis
  • Antibiotics, Antineoplastic / isolation & purification
  • Antibiotics, Antineoplastic / pharmacology*
  • Cell Line, Tumor
  • Chemical Phenomena
  • Chemistry, Physical
  • Humans
  • Indoles / isolation & purification
  • Indoles / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Mycelium / chemistry
  • Pyrroles / isolation & purification
  • Pyrroles / pharmacology*
  • Spectrophotometry, Ultraviolet
  • Streptomyces / chemistry
  • Streptomyces / metabolism*

Substances

  • Antibiotics, Antineoplastic
  • Indoles
  • JBIR-11
  • Pyrroles