Isolated single coronary artery: a series of 10 cases

Circ J. 2008 Aug;72(8):1254-8. doi: 10.1253/circj.72.1254.


Background: Isolated single coronary artery (SCA) is an extremely rare congenital coronary anomaly. Some subgroups of SCA can lead to angina pectoris, acute myocardial infarction or even sudden death in the absence of atherosclerosis. Young patients, especially, have the risk of serious clinical events, but middle-aged-to elderly patients have a variable clinical course.

Methods and results: The aim of this study was to present the clinical and angiographic properties, relatively long-term follow-up (54+/-14 months) and management of adult patients (mean age 57+/-12 years) with SCA. The records of 70,850 patients undergoing coronary angiography between 1999 and 2005 were reviewed. Ten patients (0.024%) were found to have SCA, originating from the left sinus of Valsalva in 3 (30%) patients and from the right sinus of Valsalva in 7 patients (70%). No atherosclerotic involvement was seen in 7 (70%) patients. One patient was also treated by stent implantation to the SCA. Other patients were followed medically. All patients have been followed uneventfully.

Conclusion: Medical treatment is usually adequate for middle-aged to elderly patients with SCA in the absence of ischemia and/or acute coronary syndrome.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Angina Pectoris / etiology
  • Angina Pectoris / pathology
  • Angioplasty, Balloon, Coronary / instrumentation
  • Cardiovascular Agents / therapeutic use
  • Coronary Angiography
  • Coronary Artery Disease / etiology
  • Coronary Artery Disease / pathology
  • Coronary Vessel Anomalies / complications
  • Coronary Vessel Anomalies / pathology*
  • Coronary Vessel Anomalies / therapy
  • Coronary Vessels / pathology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Sinus of Valsalva / abnormalities
  • Stents
  • Time Factors
  • Treatment Outcome
  • Turkey


  • Cardiovascular Agents