Cardiac manifestations of Weber-Christian disease: report and review of the literature

J Rheumatol. 1991 May;18(5):756-60.


A patient with chronic systemic Weber-Christian disease who was treated with hydroxychloroquine developed cardiac dilatation with congestive heart failure. Endomyocardial biopsy demonstrated myocyte degeneration and interstitial fibrosis, but no typical features of chloroquine induced cardiomyopathy. Clinical symptoms of congestive heart failure also were recognized in 7 of the 11 reported autopsy cases of Weber-Christian disease having cardiac involvement. This involvement can affect the pericardium and the myocardium.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Female
  • Heart Failure / etiology
  • Heart Failure / pathology*
  • Humans
  • Hydroxychloroquine / therapeutic use
  • Male
  • Middle Aged
  • Myocardium / pathology
  • Panniculitis, Nodular Nonsuppurative / complications
  • Panniculitis, Nodular Nonsuppurative / drug therapy
  • Panniculitis, Nodular Nonsuppurative / pathology*


  • Hydroxychloroquine