New mechanisms and therapeutic potential of curcumin for colorectal cancer
- PMID: 18655004
- DOI: 10.1002/mnfr.200700280
New mechanisms and therapeutic potential of curcumin for colorectal cancer
Abstract
Curcumin is a polyphenol derived from Curcuma longa. Over the last few years, a number of studies have provided evidence of its main pharmacological properties including chemosensitizing, radiosensitizing, wound healing activities, antimicrobial, antiviral, antifungical, immunomodulatory, antioxidant and anti-inflammatory. More recent data provide interesting insights into the effect of this compound on cancer chemoprevention and chemotherapy. In fact, preclinical studies have shown its ability to inhibit carcinogenesis in various types of cancer including colorectal cancer (CRC). Curcumin has the capacity of interact with multiple molecular targets affecting the multistep process of carcinogenesis. Also, curcumin is able to arrest the cell cycle, to inhibit the inflammatory response and the oxidative stress and to induce apoptosis in cancer cells. Likewise, it has been shown to possess marked antiangiogenic properties. Furthermore, curcumin potentiates the growth inhibitory effect of cyclo-oxygenase (COX)-2 inhibitors and traditional chemotherapy agents implicating another promising therapy regimen in the future treatment of CRC. However, its clinical advance has been hindered by its short biological half-life and low bioavailability after oral administration. This review is intended to provide the reader an update of the bioavailability and pharmacokinetics of curcumin and describes the recently identified molecular pathways responsible of its anticancer potential in CRC.
Comment in
-
Increasing the solubility of the nutraceutical curcumin by heat and inhibition of oxidative modification.Mol Nutr Food Res. 2009 Feb;53(2):308. doi: 10.1002/mnfr.200990003. Mol Nutr Food Res. 2009. PMID: 19198014 Free PMC article. No abstract available.
Similar articles
-
Curcumin for chemoprevention of colon cancer.Cancer Lett. 2007 Oct 8;255(2):170-81. doi: 10.1016/j.canlet.2007.03.005. Epub 2007 Apr 19. Cancer Lett. 2007. PMID: 17448598
-
Anticancer potential of curcumin: preclinical and clinical studies.Anticancer Res. 2003 Jan-Feb;23(1A):363-98. Anticancer Res. 2003. PMID: 12680238 Review.
-
Curcumin: the story so far.Eur J Cancer. 2005 Sep;41(13):1955-68. doi: 10.1016/j.ejca.2005.05.009. Eur J Cancer. 2005. PMID: 16081279 Review.
-
Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent.Mol Nutr Food Res. 2008 Jun;52 Suppl 1:S103-27. doi: 10.1002/mnfr.200700238. Mol Nutr Food Res. 2008. PMID: 18496811 Review.
-
Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model.Cancer Lett. 2008 Jun 18;264(2):299-308. doi: 10.1016/j.canlet.2008.01.041. Epub 2008 Mar 14. Cancer Lett. 2008. PMID: 18342436
Cited by
-
Exploring the Enhanced Antiproliferative Activity of Turmeric Oil and 6-Mercaptopurine in a Combined Nano-Particulate System Formulation.Pharmaceutics. 2023 Jul 7;15(7):1901. doi: 10.3390/pharmaceutics15071901. Pharmaceutics. 2023. PMID: 37514087 Free PMC article.
-
Pharmacological Profile, Bioactivities, and Safety of Turmeric Oil.Molecules. 2022 Aug 9;27(16):5055. doi: 10.3390/molecules27165055. Molecules. 2022. PMID: 36014301 Free PMC article. Review.
-
Camel whey protein hydrolysates induced G2/M cellcycle arrest in human colorectal carcinoma.Sci Rep. 2021 Mar 29;11(1):7062. doi: 10.1038/s41598-021-86391-z. Sci Rep. 2021. PMID: 33782460 Free PMC article.
-
Turmeric Is Therapeutic in Vivo on Patient-Derived Colorectal Cancer Xenografts: Inhibition of Growth, Metastasis, and Tumor Recurrence.Front Oncol. 2021 Jan 19;10:574827. doi: 10.3389/fonc.2020.574827. eCollection 2020. Front Oncol. 2021. PMID: 33552955 Free PMC article.
-
Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells.J Cancer. 2020 Sep 25;11(22):6704-6715. doi: 10.7150/jca.45176. eCollection 2020. J Cancer. 2020. PMID: 33046993 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
