[Effect of combined therapy with hypha Cordyceps and ginkgo leaf tablet on micro-inflammation in patients undergoing maintenance hemodialysis]

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Jun;28(6):502-4.
[Article in Chinese]


Objective: To investigate the status of the micro-inflammation in patients undergoing maintenance hemodialysis and the effect of combined therapy with hypha cordyceps and ginkgo leaf tablet for its prevention and treatment.

Methods: Sixty-five patients undergoing long-term maintenance hemodialysis were randomly assigned to the treated group (33 patients) and the control group (32 patients). Patients in both groups underwent hemodialysis regularly, meanwhile, 3 capsules of Jinshuibao (each capsule containing hypha cordyceps 0.33 g) and 1 tablet of ginkgo leaf tablet (0.23 g/tablet) were additiolally given to the patients in the treated group orally, 3 times per day, and 3 months as 1 treatment course. Their serum inflammatory factors, such as high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), which could reveal the state of microinflammation, were determined before and after treatment. And the same index was also determined in 30 healthy persons allocated in a normal control group.

Results: Compared with the normal control group, the serum levels of hs-CRP (4.94 +/- 2.21 mg/L), IL-6 (0.472 +/- 0.220 microg/L) and TNF-alpha (1.748 +/- 0.724 microg/L) in the treated group were higher before treatment, these indexes decreased markedly after treatment (3.28 +/- 1.28 mg/L, 0.379 +/- 0.163 microg/L, and 1.330 +/- 0.458 microg/L, respectively, all P < 0.01), but without significant change in the control group.

Conclusion: Micro-inflammation reaction exists popularly in patients undergoing maintenance hemodialysis, and the combined therapy with hypha cordyceps and ginkgo leaf tablet could effectively improve this kind of micro-inflammation reaction.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Cordyceps / chemistry*
  • Drug Therapy, Combination
  • Drugs, Chinese Herbal / administration & dosage
  • Drugs, Chinese Herbal / pharmacology*
  • Female
  • Ginkgo biloba / chemistry*
  • Humans
  • Hyphae / chemistry*
  • Inflammation / blood
  • Inflammation / drug therapy*
  • Inflammation / etiology
  • Inflammation / prevention & control
  • Inflammation Mediators / blood
  • Male
  • Middle Aged
  • Plant Leaves / chemistry*
  • Renal Dialysis / adverse effects*
  • Tablets


  • Drugs, Chinese Herbal
  • Inflammation Mediators
  • Tablets