Investigating connectivity between the cerebellum and thalamus in schizophrenia using diffusion tensor tractography: a pilot study

Psychiatry Res. 2008 Aug 30;163(3):193-200. doi: 10.1016/j.pscychresns.2007.10.005. Epub 2008 Jul 25.


Connections of the cortical-thalamic-cerebellar-cortical regions provide a framework for studying the neural substrates of schizophrenia. A novel diffusion tensor tractography method was used to evaluate the differences in white matter connectivity between 12 patients with schizophrenia and 10 controls. For the tract tracing, we focused on the connection between the cerebellum and the thalamus. Fractional anisotropy (FA) measures along the fiber tracks were compared between patients and the control sample. Fiber tracts located between the cerebellar white matter and the thalamus exhibit a reduced FA in patients with schizophrenia in comparison with controls. The FA values along the defined fiber tracts were not overall reduced but exhibited a reduction in the anisotropy in the region in the superior cerebellar peduncles projecting towards the red nucleus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anisotropy
  • Cerebellum / physiopathology*
  • Diagnostic and Statistical Manual of Mental Disorders
  • Diffusion Magnetic Resonance Imaging*
  • Female
  • Humans
  • Male
  • Nerve Net / physiopathology*
  • Pilot Projects
  • Schizophrenia / physiopathology*
  • Thalamus / physiopathology*