Importance of hyaluronan-CD44 interactions in inflammation and tumorigenesis

Connect Tissue Res. 2008;49(3):215-8. doi: 10.1080/03008200802143323.


Hyaluronan is an apparently simple polysaccharide that is responsible for tissue hydration but also stimulates cell proliferation, migration, and differentiation via binding to cell surface receptors, such as CD44. The amounts of hyaluronan increase during inflammation and tumorigenesis through the action of chemokines and growth factors. This review discusses some of the evidence that hyaluronan-CD44 complexes trigger signaling cascades that modulate inflammation and tumor progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Movement
  • Cell Proliferation
  • Disease Progression
  • Fibrosis / metabolism
  • Humans
  • Hyaluronan Receptors / metabolism*
  • Hyaluronic Acid / metabolism*
  • Inflammation / metabolism*
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Signal Transduction


  • Hyaluronan Receptors
  • Hyaluronic Acid