Predictors and early and late outcomes of dialysis-dependent patients in contemporary cardiac surgery

J Cardiothorac Vasc Anesth. 2008 Aug;22(4):522-9. doi: 10.1053/j.jvca.2008.01.015. Epub 2008 Apr 8.


Objectives: The aim of the study was to investigate the incidence and predictors of renal failure requiring dialysis (RF-D) in a contemporary cohort of patients undergoing cardiac surgery. The authors also analyzed early and late outcome of patients with this complication.

Design: A retrospective study of consecutive patients undergoing cardiac surgery using a computerized database based on the New York State Department of Health registry. Data collection was performed prospectively.

Setting: A university hospital (single institution).

Participants: Six thousand four hundred forty-nine patients who underwent cardiac surgery between January 1998 and December 2006 including isolated coronary artery bypass graft (CABG) surgery (n = 2,819, 44%), single- or multiple-valve surgery (n = 1,378, 21%), combined valve and CABG procedures (n = 1,032, 16%), and surgery involving the ascending aorta or the aortic arch (n = 1,220, 19%).

Interventions: None.

Measurements and main results: The incidence of RF-D was 2.2% (n = 139). The incidence per type of procedure was as follows: CABG surgery (0.8%), valve/CABG surgery (2.7%), valve surgery (2.9%), and aortic surgery (4%) (p = 0.001). Multivariate analysis revealed preoperative renal dysfunction (odds ratio [OR] = 5.5), hemodynamic instability (OR = 5.2), diabetes (OR = 2.6), aortic surgery (OR = 2.2), congestive heart failure (CHF) (OR = 2.1), peripheral vascular disease (PVD) (OR = 1.9), and reoperation (OR = 1.8) as independent predictors of RF-D. The hospital mortality after RF-D was 36.7% (n = 51) compared with 2.9% (n = 180) in the control group (p < 0.001). Long-term survival after RF-D was significantly decreased (1-year and 5-year survival 48.5% +/- 6.1% and 28.7% +/- 7.2% v 94.5% +/- 0.3% and 83.5% +/- 0.6% in the control group, p < 0.001). Hypertension, CHF, and PVD were independent predictors of late mortality.

Conclusion: The authors observed an increase in the overall incidence of RF-D compared with previous studies, probably related to an increased prevalence of patients undergoing more complex procedures with a worsening risk profile. Postoperative RF-D was not only associated with increased hospital mortality and morbidity, but also with a significant reduction of long-term survival in discharged patients. Seven independent predictors of RF-D were identified. Future research efforts should focus on a more precise identification of patients at risk and the development of new treatment modalities, which would potentially prevent the occurrence of this complication.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cardiovascular Surgical Procedures / adverse effects*
  • Cardiovascular Surgical Procedures / trends*
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Postoperative Complications / epidemiology
  • Postoperative Complications / etiology
  • Postoperative Complications / therapy
  • Predictive Value of Tests
  • Prospective Studies
  • Renal Dialysis / trends*
  • Renal Insufficiency / epidemiology
  • Renal Insufficiency / etiology
  • Renal Insufficiency / therapy
  • Retrospective Studies
  • Risk Factors
  • Time Factors
  • Treatment Outcome