The Aurora kinase family in cell division and cancer

Biochim Biophys Acta. 2008 Sep;1786(1):60-72. doi: 10.1016/j.bbcan.2008.07.003. Epub 2008 Jul 23.

Abstract

The Aurora protein kinase family (consisting of Aurora-A, -B and -C) is an important group of enzymes that controls several aspects of cell division in mammalian cells. Dysfunction of these kinases has been associated with a failure to maintain a stable chromosome content, a state that can contribute to tumourigenesis. Additionally, Aurora-A is frequently found amplified in a variety of tumour types and displays oncogenic activity. On the other hand, therapeutic inhibition of these kinases has shown great promise as potential anti-cancer treatment, most likely because of their essential roles during cell division. This review will focus on our present understanding of the different roles played by these kinases, their regulation throughout cell division, their deregulation in human cancers and on the progress that is made in targeting these important regulators in the treatment of cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anaphase / physiology
  • Aurora Kinases
  • Cell Division / physiology*
  • Centrosome / physiology
  • Chromatids / physiology
  • Cytokinesis / physiology
  • Enzyme Activation
  • Humans
  • Mitosis / physiology
  • Neoplasms / drug therapy
  • Neoplasms / enzymology*
  • Neoplasms / etiology
  • Protein Kinase Inhibitors / therapeutic use
  • Protein-Serine-Threonine Kinases / antagonists & inhibitors
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism*
  • Spindle Apparatus / physiology

Substances

  • Protein Kinase Inhibitors
  • Aurora Kinases
  • Protein-Serine-Threonine Kinases