Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Oct;18(10):701-11.
doi: 10.1016/j.euroneuro.2008.06.007. Epub 2008 Jul 26.

The Circadian Basis of Mood Disorders: Recent Developments and Treatment Implications

Affiliations
Review

The Circadian Basis of Mood Disorders: Recent Developments and Treatment Implications

Palmiero Monteleone et al. Eur Neuropsychopharmacol. .

Abstract

In humans, most physiological and behavioural functions demonstrate a circadian rhythmicity, which is essential to adequately cope with dramatic fluctuations occurring in the external environment. Therefore, it is intuitive that alterations in the endogenous machinery regulating circadian oscillations may lead to physical and mental symptoms and morbidities. Mood disorders, especially unipolar depression and seasonal affective disorder, have been linked to circadian rhythm abnormalities. This paper provides a brief description of the molecular and genetic mechanisms regulating the endogenous clock system and reviews selected studies describing circadian abnormalities in patients with depression. Evidence is emerging that a disruption of the normal circadian rhythmicity occurs at least in a subgroup of depressed patients and that interventions able to resynchronize the human circadian system, including sleep deprivation, light therapy and drugs specifically acting on the endogenous clock system, have proven antidepressant effects. It seems likely that, in the future, the knowledge coming from the exploration of molecular and genetic mechanisms involved in the physiology of the circadian clock system will be fruitful for a deeper understanding of the etiopathogenesis of mood disorders and the development of more effective therapeutic strategies.

Similar articles

See all similar articles

Cited by 48 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback