Abstract
We demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T helper cell (Th17) clones and that all IL-17-producing cells are contained in the CD161(+) fraction of CD4(+) T cells present in the circulation or in inflamed tissues, although they are not CD1-restricted natural killer T cells. More importantly, we show that all IL-17-producing cells originate from CD161(+) naive CD4(+) T cells of umbilical cord blood, as well as of the postnatal thymus, in response to the combined activity of IL-1 beta and IL-23. These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161(+)CD4(+) T cell progenitor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antigens, Surface / genetics*
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Antigens, Surface / metabolism*
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CD4-Positive T-Lymphocytes / cytology
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CD4-Positive T-Lymphocytes / immunology*
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Case-Control Studies
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Cell Differentiation
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Crohn Disease / genetics
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Crohn Disease / immunology
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Fetal Blood / cytology
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Fetal Blood / immunology
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Hematopoietic Stem Cells / cytology
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Hematopoietic Stem Cells / immunology
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Humans
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Infant, Newborn
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Inflammation / genetics
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Inflammation / immunology
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Inflammation / pathology
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Interleukin-17 / biosynthesis*
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Lectins, C-Type / genetics*
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Lectins, C-Type / metabolism*
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NK Cell Lectin-Like Receptor Subfamily B
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Nuclear Receptor Subfamily 1, Group F, Member 3
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Psoriasis / genetics
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Psoriasis / immunology
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Receptors, Interleukin / genetics
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Receptors, Retinoic Acid / genetics
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Receptors, Thyroid Hormone / genetics
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T-Lymphocyte Subsets / cytology
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T-Lymphocyte Subsets / immunology*
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Th1 Cells / cytology
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Th1 Cells / immunology
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Th2 Cells / cytology
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Th2 Cells / immunology
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Thymus Gland / cytology
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Thymus Gland / immunology
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Up-Regulation
Substances
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Antigens, Surface
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IL23R protein, human
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Interleukin-17
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KLRB1 protein, human
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Lectins, C-Type
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NK Cell Lectin-Like Receptor Subfamily B
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Nuclear Receptor Subfamily 1, Group F, Member 3
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RNA, Messenger
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RORC protein, human
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Receptors, Interleukin
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Receptors, Retinoic Acid
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Receptors, Thyroid Hormone