Enhancement characteristics of ultrasmall superparamagnetic iron oxide particle within the prostate gland in patients with primary prostate cancer

J Comput Assist Tomogr. 2008 Jul-Aug;32(4):523-8. doi: 10.1097/RCT.0b013e318136e194.

Abstract

Objective: To analyze the enhancement of the prostate using ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance imaging in patients with prostate cancer.

Methods: Sixty patients were enrolled. The signal-to-noise ratios (SNRs) of the central and peripheral zones (CZ and PZ, respectively) of the prostate were evaluated on T2- and T2*-weighted magnetic resonance imaging before and 24 hours after USPIO-enhanced MRI. The changes in SNR after USPIO-enhanced MRI were analyzed and correlated with serum prostate-specific antigen and histopathologic Gleason scoring based on surgically removed prostate gland.

Results: Decrease in SNR was noted in each zone of the prostate after USPIO-enhanced MRI (P < 0.001). Mean SNR decrease in the CZ was higher than that in the PZ (P < 0.05). High-grade prostate cancer was associated with a higher decrease in SNR (P < 0.05). The SNR change was negatively correlated with serum prostate-specific antigen at low or intermediate levels (P < 0.05).

Conclusions: Enhancement of the prostate gland after USPIO administration may be associated with primary prostate cancer.

Publication types

  • Evaluation Study

MeSH terms

  • Aged
  • Contrast Media / administration & dosage*
  • Dextrans
  • Ferrosoferric Oxide
  • Humans
  • Image Enhancement / methods*
  • Iron*
  • Magnetic Resonance Imaging / methods*
  • Magnetite Nanoparticles
  • Male
  • Middle Aged
  • Observer Variation
  • Oxides*
  • Prostate / pathology*
  • Prostate-Specific Antigen / blood
  • Prostatic Neoplasms / diagnosis*
  • Reproducibility of Results
  • Retrospective Studies
  • Ultrasonography, Interventional / methods

Substances

  • Contrast Media
  • Dextrans
  • Magnetite Nanoparticles
  • Oxides
  • ferumoxtran-10
  • Iron
  • Prostate-Specific Antigen
  • Ferrosoferric Oxide