Flexible bronchoscopy for diagnosis and follow up of childhood endobronchial tuberculosis

Pediatr Infect Dis J. 2008 Sep;27(9):783-7. doi: 10.1097/INF.0b013e318170fccc.

Abstract

Background: In this study, our aim was to determine the clinical and bronchoscopic outcome of the endobronchial tuberculosis (ETB).

Methods: Patients with suspected tuberculosis (TB) or TB patients with an inadequate response to 8 weeks of antituberculosis treatment were enrolled in the study.

Results: Seventy patients were included to the study and 118 flexible bronchoscopies were performed. ETB was present in 33 (47%) patients. There was isolated compression in 14 cases, caseous lesions in 13, granuloma formation in 6, polypoid lesions in 2, adenopathy protrusion in 1, and mucosal erosion in 1 case. The mean duration of bronchoscopic resolution of endobronchial lesions was 5.50 +/- 2.74 months. Mycobacterium tuberculosis was isolated from gastric lavage in 10% and from bronchoalveolar lavage in 12.8% of 70 cases. When both of the procedures were performed concurrently, the isolation rate increased to 20%. Transient hypoxia resolving with nasal O2 was observed in 3 patients as a complication of bronchoscopy.

Conclusions: Bronchoscopy offered a safe and rapid means of confirming the diagnosis of ETB.

Publication types

  • Clinical Trial

MeSH terms

  • Bronchial Diseases / diagnosis*
  • Bronchial Diseases / pathology
  • Bronchoalveolar Lavage Fluid / microbiology
  • Bronchoscopy / adverse effects*
  • Bronchoscopy / methods*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Hypoxia / drug therapy
  • Infant
  • Infant, Newborn
  • Male
  • Mycobacterium tuberculosis / isolation & purification*
  • Oxygen / therapeutic use
  • Stomach / microbiology
  • Tuberculosis / diagnosis*
  • Tuberculosis / pathology

Substances

  • Oxygen