Lipid Nanoparticles With a Solid Matrix (SLN, NLC, LDC) for Oral Drug Delivery

Drug Dev Ind Pharm. 2008 Dec;34(12):1394-405. doi: 10.1080/03639040802130061.


Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid-drug conjugates (LDC), commonly produced by high-pressure homogenization, are interesting vectors for oral delivery of lipophilic and, to a certain extent, hydrophilic substances. Their production can be done without the use of organic solvents. Techniques to make them a physically stable delivery system have been developed. Scaling up of the production process from lab-size to large-scale dimensions using high-pressure homogenization can be easily achieved by using a different type of homogenizer. The machines used for large-scale production often yield an even better product quality than the lab-scale types. This review article covers the methods of production, characterization, mechanisms of oral bioavailability enhancement, scale-up, final oral dosage forms, and regulatory aspects of lipid nanoparticles for oral drug delivery. It focuses mainly on high-pressure homogenization production methods.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Administration, Oral
  • Drug Delivery Systems*
  • Intestinal Absorption
  • Lipids / chemistry*
  • Nanoparticles / chemistry*
  • Technology, Pharmaceutical


  • Lipids