Linking calcium to Abeta and Alzheimer's disease

Neuron. 2008 Jul 31;59(2):190-4. doi: 10.1016/j.neuron.2008.07.013.


Recent developments point to a critical role for calcium dysregulation in the pathogenesis of Alzheimer's disease. A novel calcium-conducting channel called CALHM1 is genetically linked to the disorder and modulates Abeta production. Calcium homeostasis has also been shown to be perturbed in dendritic spines adjacent to amyloid plaques. Finally, new studies have elucidated the role by which presenilins modulate calcium signaling, including effects on SERCA2b and gating of the IP(3) receptor, and lead to Abeta production.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology
  • Amyloid beta-Peptides / genetics
  • Amyloid beta-Peptides / metabolism*
  • Animals
  • Calcium / metabolism*
  • Calcium / physiology
  • Calcium Channels / physiology
  • Humans
  • Membrane Glycoproteins / metabolism
  • Membrane Glycoproteins / physiology


  • Amyloid beta-Peptides
  • CALHM1 protein, human
  • Calcium Channels
  • Membrane Glycoproteins
  • Calcium