Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat

Surg Today. 2008;38(8):716-25. doi: 10.1007/s00595-007-3706-2. Epub 2008 Jul 31.

Abstract

Purpose: Stable gastric pentadecapeptide BPC 157 accelerates the healing of a transected Achilles tendon and a transected quadriceps muscle. It may also be of clinical relevance as a systemic and local peptide treatment for crush injury of a major muscle, such as gastrocnemius muscle complex. BPC 157 is effective without a carrier, and it is presently undergoing trials for inflammatory bowel disease, and no toxicity has so far been reported.

Methods: In crushed rats (force delivered 0.727 Ns/cm2), BPC 157 was applied either intraperitoneally or locally, as a thin cream layer, immediately after injury (sacrifice at 2 h), and once a day for 14 days.

Results: BPC 157 improved muscle healing, macroscopically (less hematoma and edema, no post-injury leg contracture), microscopically, functionally, and also based on enzyme activity (creatine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase).

Conclusion: BPC 157, at all investigated intervals, given locally or intraperitoneally, accelerated post-injury muscle healing and also helped to restore the full function.

MeSH terms

  • Achilles Tendon / drug effects*
  • Achilles Tendon / injuries
  • Achilles Tendon / physiopathology
  • Animals
  • Male
  • Peptide Fragments / pharmacology*
  • Proteins / pharmacology*
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Recovery of Function
  • Statistics, Nonparametric
  • Stress, Mechanical
  • Tendon Injuries / drug therapy*
  • Tendon Injuries / physiopathology
  • Wound Healing / drug effects*
  • Wound Healing / physiology

Substances

  • Peptide Fragments
  • Proteins
  • BPC 157