[Inhibitory mechanism of melanin synthesis by glutathione]

Yakugaku Zasshi. 2008 Aug;128(8):1203-7. doi: 10.1248/yakushi.128.1203.
[Article in Japanese]


Glutathione dose dependently inhibited melanin synthesis in the reaction of tyrosinase and L-DOPA. The inhibition of melanin synthesis was recovered by increasing the concentration of L-DOPA, but not recovered by increasing tyrosinase. Glutathione inhibited the binding between tyrosinase and L-DOPA. Although the synthesized melanin was aggregated within 1 h, the aggregation was inhibited by the addition of glutathione. These results indicate that glutathione inhibits the synthesis and agglutination of melanin by interrupting the function of L-DOPA.

Publication types

  • English Abstract

MeSH terms

  • Agglutination
  • Depression, Chemical
  • Dose-Response Relationship, Drug
  • Glutathione / pharmacology*
  • Levodopa*
  • Melanins / biosynthesis*
  • Monophenol Monooxygenase*
  • Protein Binding / drug effects


  • Melanins
  • Levodopa
  • Monophenol Monooxygenase
  • Glutathione