VE-cadherin and claudin-5: it takes two to tango

Nat Cell Biol. 2008 Aug;10(8):883-5. doi: 10.1038/ncb0808-883.


The endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, two key components of adherens and tight endothelial junctions, respectively. Emerging evidence that VE-cadherin controls claudin-5 expression by preventing the nuclear accumulation of FoxO1 and β-catenin, which repress the claudin-5 promoter, provides a crosstalk between these endothelial junctional structures.

Publication types

  • Comment
  • News

MeSH terms

  • Adherens Junctions / physiology*
  • Animals
  • Antigens, CD / physiology*
  • Cadherins / physiology*
  • Claudin-5
  • Humans
  • Membrane Proteins / genetics*
  • Tight Junctions
  • Up-Regulation / genetics


  • Antigens, CD
  • CLDN5 protein, human
  • Cadherins
  • Claudin-5
  • Membrane Proteins
  • cadherin 5