IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription

FEBS Lett. 2008 Aug 20;582(19):2833-7. doi: 10.1016/j.febslet.2008.07.033. Epub 2008 Jul 29.


Jun-dimerization protein 2 (JDP2) is a member of the activating protein-1 (AP-1) family of transcription factors. JDP2 dimerizes with other AP-1 proteins such as activating transcription factor-2 (ATF2) and Jun to repress transcription from promoters that contain a cyclic AMP-responsive element (CRE). Interferon regulatory factor-2-binding protein-1 (IRF2-BP1), which is reported to be a transcriptional corepressor of IRF2, was isolated as a JDP2-binding protein using an epitope-tagging method. As anticipated from the presence of a RING-finger domain, IRF2-BP1 enhanced the polyubiquitination of JDP2. Moreover, IRF2-BP1 repressed ATF2-mediated transcriptional activation from a CRE-containing promoter.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activating Transcription Factor 2 / antagonists & inhibitors
  • Activating Transcription Factor 2 / metabolism*
  • Amino Acid Sequence
  • Carrier Proteins / metabolism*
  • Genes, Reporter
  • HeLa Cells
  • Humans
  • Luciferases / genetics
  • Molecular Sequence Data
  • Promoter Regions, Genetic
  • Repressor Proteins / metabolism*
  • Transcription, Genetic
  • Transcriptional Activation*
  • Ubiquitin-Protein Ligases / metabolism*
  • Ubiquitination*


  • ATF2 protein, human
  • Activating Transcription Factor 2
  • Carrier Proteins
  • JDP2 protein, human
  • Repressor Proteins
  • Luciferases
  • IRF2BP1 protein, human
  • Ubiquitin-Protein Ligases