Abstract
Ocimum selloi essential oil (2, 20, and 200 mg/kg; p.o.) reduced, in a dose-dependent way, the abdominal contraction induced by acetic acid (0.6%; i.p.) and the diarrhea episodes induced by castor oil in mice. At the higher dose (200 mg/kg; p.o.), the essential oil significantly reduced intestinal transit (P<0.05) in the charcoal meal test. The main component detected in O. selloi essential oil was methyl chavicol (98%; GC and GC/MS).These effects seems to support the use of O. selloi against diarrhea, intestinal spasm and visceral pain.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetic Acid
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Analgesics / therapeutic use*
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Animals
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Antidiarrheals / therapeutic use*
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Diarrhea / drug therapy*
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Dose-Response Relationship, Drug
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Gastrointestinal Transit / drug effects
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Male
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Mice
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Ocimum* / chemistry
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Oils, Volatile / isolation & purification
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Oils, Volatile / therapeutic use*
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Pain / chemically induced
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Pain / drug therapy*
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Parasympatholytics / therapeutic use
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Plant Extracts / therapeutic use*
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Plant Leaves
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Spasm / drug therapy
Substances
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Analgesics
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Antidiarrheals
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Oils, Volatile
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Parasympatholytics
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Plant Extracts
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Acetic Acid