Preclinical study of new TB drugs and drug combinations in mouse models

Recent Pat Antiinfect Drug Discov. 2008 Jun;3(2):102-16. doi: 10.2174/157489108784746579.


Tuberculosis (TB) remains one of the leading infectious killers in the world. New anti-TB drugs and more effective drug combinations are urgently needed, particularly given the increasing incidence of drug-resistant TB and HIV-TB co-infection. This review describes the available mouse models of TB and describes their utility in the evaluation of new TB drug candidates and in the evaluation of the efficacy of new TB drug combinations. Some of the most recent patents on promising TB drug-candidates are also mentioned here.

Publication types

  • Review

MeSH terms

  • Animals
  • Antitubercular Agents / chemistry
  • Antitubercular Agents / pharmacology*
  • Disease Models, Animal
  • Drug Evaluation, Preclinical*
  • Drug Resistance, Bacterial
  • Drug Therapy, Combination
  • Mice
  • Molecular Structure
  • Patents as Topic
  • Structure-Activity Relationship
  • Time Factors
  • Tuberculosis / drug therapy*


  • Antitubercular Agents