Abstract
This Letter describes a new multi-gram synthetic protocol for the preparation of the classic tosylate labeling precursor for the D(2/3) PET agent [(18)F]fallypride. In the course of our studies, we also discovered two novel labeling precusors, the previously undescribed mesylate and chloro congeners of fallypride.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzamides / pharmacology*
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Chemistry, Pharmaceutical / methods
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Chlorine / chemistry
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Dopamine D2 Receptor Antagonists
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Drug Design
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Mesylates / chemistry
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Models, Chemical
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Positron-Emission Tomography / instrumentation*
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Positron-Emission Tomography / methods
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Pyrrolidines / pharmacology*
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Radiopharmaceuticals / pharmacology*
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Receptors, Dopamine D2 / chemistry
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Receptors, Dopamine D3 / antagonists & inhibitors
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Receptors, Dopamine D3 / chemistry
Substances
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Benzamides
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Dopamine D2 Receptor Antagonists
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Mesylates
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N-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamide
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Pyrrolidines
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Radiopharmaceuticals
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Receptors, Dopamine D2
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Receptors, Dopamine D3
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Chlorine