The HPA axis in major depression: classical theories and new developments

Trends Neurosci. 2008 Sep;31(9):464-8. doi: 10.1016/j.tins.2008.06.006. Epub 2008 Jul 31.


Studies over the last 40 years have demonstrated that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Depressive Disorder, Major / physiopathology*
  • Humans
  • Hypothalamo-Hypophyseal System / physiopathology*
  • Pituitary-Adrenal System / physiopathology*
  • Receptors, Glucocorticoid / physiology*


  • Receptors, Glucocorticoid