The HPA axis in major depression: classical theories and new developments

Carmine M Pariante; Stafford L Lightman

doi:10.1016/j.tins.2008.06.006

The HPA axis in major depression: classical theories and new developments

Trends Neurosci. 2008 Sep;31(9):464-8. doi: 10.1016/j.tins.2008.06.006. Epub 2008 Jul 31.

Authors

Carmine M Pariante¹, Stafford L Lightman

Affiliation

¹ Institute of Psychiatry, King's College London, Division of Psychological Medicine and Psychiatry, Centre for the Cellular Basis of Behaviour, London, UK.

PMID: 18675469
DOI: 10.1016/j.tins.2008.06.006

Abstract

Studies over the last 40 years have demonstrated that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Depressive Disorder, Major / physiopathology*
Humans
Hypothalamo-Hypophyseal System / physiopathology*
Pituitary-Adrenal System / physiopathology*
Receptors, Glucocorticoid / physiology*

Substances

Receptors, Glucocorticoid

Abstract

Publication types

MeSH terms

Substances

Grants and funding