Nakijiquinones G-I, new sesquiterpenoid quinones from marine sponge

Bioorg Med Chem. 2008 Aug 15;16(16):7561-4. doi: 10.1016/j.bmc.2008.07.028. Epub 2008 Jul 18.

Abstract

Three new sesquiterpenoid quinones, nakijiquinones G-I (1-3), containing a different amino group derived from amino acids have been isolated from Okinawan marine sponges of the family Spongiidae, and the structures and relative stereochemistry of 1-3 were elucidated on the basis of the spectral data. Nakijiquinones G-I (1-3) showed modest cytotoxicity and inhibitory activity against HER2 kinase, while nakijiquinone H (2) exhibited antimicrobial activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Humans
  • Mice
  • Microbial Sensitivity Tests
  • Nuclear Magnetic Resonance, Biomolecular
  • Optical Rotation
  • Porifera / chemistry*
  • Quinones / chemistry*
  • Quinones / isolation & purification
  • Quinones / pharmacology*
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology*
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Anti-Bacterial Agents
  • Quinones
  • Sesquiterpenes