The effect of insulin-like growth factor-I, relaxin and luteinizing hormone on vascular endothelial growth factor secretion by cultured endometrial stromal cells on different days of early pregnancy in pigs

Reprod Biol. 2008 Jul;8(2):163-70. doi: 10.1016/s1642-431x(12)60011-4.

Abstract

The effect of insulin-like growth factor-I (IGF-I), relaxin (RLX) and luteinizing hormone (LH) on vascular endothelial growth factor (VEGF) in vitro secretion by endometrial stromal cells in pigs was investigated on days 10-12 and 20-22 of gestation. LH-stimulated stromal cell secretion of VEGF did not differ among tested days of early pregnancy. However, IGF-I- and RLX-mediated release of VEGF depended on the day of pregnancy. It seems that IGF-I and RLX may be considered as potent activators of VEGF-mediated angiogenesis in porcine endometrium, and their action may be more pronounced during maternal recognition of pregnancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cells, Cultured
  • Endometrium / cytology*
  • Female
  • Insulin-Like Growth Factor I / pharmacology*
  • Luteinizing Hormone / pharmacology*
  • Neovascularization, Physiologic / drug effects
  • Pregnancy
  • Pregnancy, Animal / physiology*
  • Relaxin / pharmacology*
  • Stromal Cells / metabolism
  • Swine
  • Time Factors
  • Vascular Endothelial Growth Factor A / metabolism*

Substances

  • Vascular Endothelial Growth Factor A
  • Insulin-Like Growth Factor I
  • Luteinizing Hormone
  • Relaxin