Synergistic interactions between the NMDA antagonist dizocilpine and the preferential dopamine autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 with regard to locomotor stimulation in monoamine-depleted mice

J Neural Transm Gen Sect. 1991;85(1):69-77. doi: 10.1007/BF01244659.

Abstract

When administered to mice pretreated with the monoamine-depleter reserpine and the catecholamine synthesis inhibitor alpha-methyl-para-tyrosine, the preferential autoreceptor antagonists (+)-AJ76 and (+)-UH 232 induced weak locomotor stimulation. When either (+)-AJ 76 or (+)-UH 232 was combined with a subthreshold dose of the selective NMDA antagonist dizocilpine (MK-801), a marked locomotor stimulation was produced in monoamine-depleted mice. The mechanism of this stimulation, although reduced by dopamine antagonists, remains to be clarified.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin* / analogs & derivatives*
  • Animals
  • Dizocilpine Maleate / metabolism
  • Dizocilpine Maleate / pharmacology
  • Dopamine Antagonists*
  • Drug Synergism
  • Locomotion / drug effects
  • Locomotion / physiology*
  • Male
  • Mice
  • Motor Activity / drug effects*
  • Motor Activity / physiology
  • N-Methylaspartate / antagonists & inhibitors
  • Tetrahydronaphthalenes / metabolism
  • Tetrahydronaphthalenes / pharmacology*

Substances

  • Dopamine Antagonists
  • Tetrahydronaphthalenes
  • N-Methylaspartate
  • Dizocilpine Maleate
  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • 5-methoxy-1-methyl-2-(n-propylamino)tetralin
  • UH 232