Juvenile Hormone Analogues, methoprene and fenoxycarb dose-dependently enhance certain enzyme activities in the silkworm Bombyx mori (L)

Int J Environ Res Public Health. 2008 Jun;5(2):120-4. doi: 10.3390/ijerph5020120.


Use of Juvenile Hormone Analogues (JHA) in sericulture practices has been shown to boost good cocoon yield; their effect has been determined to be dose-dependent. We studied the impact of low doses of JHA compounds such as methoprene and fenoxycarb on selected key enzymatic activities of the silkworm Bombyx mori. Methoprene and fenoxycarb at doses of 1.0 microg and 3.0 fg/larvae/48 hours showed enhancement of the 5th instar B. mori larval muscle and silkgland protease, aspartate aminotransaminase (AAT) and alanine aminotransaminase (ALAT), adenosine triphosphate synthase (ATPase) and cytochrome-c-oxidase (CCO) activity levels, indicating an upsurge in the overall oxidative metabolism of the B.mori larval tissues.

MeSH terms

  • Adenosine Triphosphatases / drug effects
  • Alanine Transaminase / drug effects
  • Animals
  • Aspartate Aminotransferases / drug effects
  • Bombyx / drug effects*
  • Bombyx / enzymology*
  • Bombyx / physiology
  • Dose-Response Relationship, Drug
  • Electron Transport Complex IV / drug effects
  • Energy Metabolism / drug effects
  • Energy Metabolism / physiology
  • Gene Expression Regulation, Developmental
  • Juvenile Hormones / metabolism
  • Larva / drug effects
  • Larva / growth & development
  • Metamorphosis, Biological / drug effects
  • Metamorphosis, Biological / physiology
  • Methoprene / pharmacology*
  • Phenylcarbamates / pharmacology*


  • Juvenile Hormones
  • Phenylcarbamates
  • Methoprene
  • Electron Transport Complex IV
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Adenosine Triphosphatases
  • fenoxycarb