Jamming the ratchet of transcription

Nat Struct Mol Biol. 2008 Aug;15(8):777-9. doi: 10.1038/nsmb0808-777.


The exact mechanism by which cellular RNA polymerases translocate and maintain exceptionally high fidelity during transcription remains a major unresolved issue. Two recent structural studies of yeast RNA polymerase II in complex with its potent inhibitor, the fungal toxin α-amanitin, address this matter by describing critical and surprising details about the enzyme catalytic center dynamic organization.

Publication types

  • Comment
  • News
  • Research Support, N.I.H., Extramural

MeSH terms

  • Alpha-Amanitin / chemistry
  • DNA / chemistry
  • Fungal Proteins / chemistry
  • Gene Deletion
  • Models, Biological
  • Models, Molecular
  • Nucleotides / chemistry
  • Protein Conformation
  • Protein Structure, Secondary
  • Protein Transport
  • RNA Polymerase II / metabolism*
  • Transcription, Genetic*
  • Yeasts


  • Alpha-Amanitin
  • Fungal Proteins
  • Nucleotides
  • DNA
  • RNA Polymerase II