Ten mg dexrabeprazole daily is as effective as 20 mg rabeprazole daily

World J Gastroenterol. 2008 Jul 28;14(28):4586-7. doi: 10.3748/wjg.14.4586.

Abstract

Ten mg dexrabeprazole daily has been shown to be more effective than 20 mg rabeprazole daily against gastroesophageal reflux disease (GERD). This report shows that the efficacy of 10 mg dexrabeprazole daily is equivalent to that of 20 mg dexrabeprazole daily against GERD. This implies that a dose of 10 mg dexrabeprazole is sufficient to block the maximum amount of proton pumps without any need to double the dose as suggested with rabeprazole.

Publication types

  • Letter
  • Randomized Controlled Trial
  • Comment

MeSH terms

  • 2-Pyridinylmethylsulfinylbenzimidazoles / administration & dosage*
  • 2-Pyridinylmethylsulfinylbenzimidazoles / adverse effects
  • Adolescent
  • Adult
  • Aged
  • Anti-Ulcer Agents / administration & dosage*
  • Anti-Ulcer Agents / adverse effects
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Gastroesophageal Reflux / drug therapy*
  • Humans
  • Male
  • Middle Aged
  • Proton Pump Inhibitors
  • Rabeprazole
  • Treatment Outcome
  • Young Adult

Substances

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Anti-Ulcer Agents
  • Proton Pump Inhibitors
  • Rabeprazole