Siderophores in fungal physiology and virulence

Annu Rev Phytopathol. 2008:46:149-87. doi: 10.1146/annurev.phyto.45.062806.094338.


Maintaining the appropriate balance of iron between deficiency and toxicity requires fine-tuned control of systems for iron uptake and storage. Both among fungal species and within a single species, different systems for acquisition, storage, and regulation of iron are present. Here we discuss the most recent findings on the mechanisms involved in maintaining iron homeostasis with a focus on siderophores, low-molecular-mass iron chelators, employed for iron uptake and storage. Recently siderophores have been found to be crucial for pathogenicity of animal, as well as plant-pathogenic fungi and for maintenance of plant-fungal symbioses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Fungal Proteins / metabolism
  • Fungi / pathogenicity*
  • Fungi / physiology*
  • Iron / metabolism
  • Plant Diseases / microbiology*
  • Siderophores / physiology*


  • Fungal Proteins
  • Siderophores
  • Iron