Direct access to anthranilic acid derivatives via CO2 incorporation reaction using arynes

Hiroto Yoshida; Takami Morishita; Joji Ohshita

doi:10.1021/ol801588s

Direct access to anthranilic acid derivatives via CO2 incorporation reaction using arynes

Org Lett. 2008 Sep 4;10(17):3845-7. doi: 10.1021/ol801588s. Epub 2008 Aug 6.

Authors

Hiroto Yoshida¹, Takami Morishita, Joji Ohshita

Affiliation

¹ Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527, Japan. yhiroto@hiroshima-u.ac.jp

PMID: 18681452
DOI: 10.1021/ol801588s

Abstract

CO2 was found to be directly convertible into anthranilic acid derivatives of great synthetic value through a three-component coupling using arynes and amines. Zwitterions arising from nucleophilic attack of amines to arynes serve as key intermediates in the coupling.