Abstract
The ATP-binding cassette transporter ABCG2 (BCRP, MXR and ABCP) is highly expressed in the gastrointestinal tract and liver, and governs absorption, distribution and excretion of a wide variety of clinically important drugs. Common germline polymorphisms in the ABCG2 gene have been described that can affect expression, cellular localization and/or substrate recognition of the encoded protein. Alteration of transporter function by either of these mechanisms contributes significantly to interindividual variability in drug disposition and treatment outcome with certain, but not all, substrates for ABCG2.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily G, Member 2
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ATP-Binding Cassette Transporters / genetics*
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ATP-Binding Cassette Transporters / physiology
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Animals
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Drug Resistance, Multiple / drug effects
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Drug Resistance, Multiple / genetics*
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Drug Resistance, Multiple / physiology
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Drug-Related Side Effects and Adverse Reactions
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Genetic Variation / drug effects
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Genetic Variation / physiology
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Humans
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Neoplasm Proteins / genetics*
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Neoplasm Proteins / physiology
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Pharmaceutical Preparations / administration & dosage*
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Pharmaceutical Preparations / metabolism
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Pharmacogenetics / methods
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Pharmacogenetics / trends*
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Polymorphism, Genetic / drug effects
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Polymorphism, Genetic / physiology
Substances
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ABCG2 protein, human
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ATP Binding Cassette Transporter, Subfamily G, Member 2
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ATP-Binding Cassette Transporters
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Neoplasm Proteins
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Pharmaceutical Preparations