Abstract
Polyglutamine expansion diseases are triggered by the accumulation of toxic proteins. A new study reports that RNA molecules containing long CAG repeats can also be toxic to neurons and may play a significant role in pathogenesis.
MeSH terms
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Animals
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Base Sequence
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Drosophila / genetics*
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Drosophila / metabolism
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Drosophila / physiology
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Drosophila Proteins / genetics
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Drosophila Proteins / metabolism
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Drosophila Proteins / physiology
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Glutamine / genetics
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Glutamine / metabolism*
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Molecular Sequence Data
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Neurodegenerative Diseases / genetics*
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Neurodegenerative Diseases / metabolism
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Neurons / metabolism
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Neurons / physiology
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Nuclear Proteins / physiology
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Peptides / genetics
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Peptides / metabolism*
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RNA / chemistry*
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RNA / metabolism
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Trinucleotide Repeat Expansion*
Substances
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Drosophila Proteins
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Nuclear Proteins
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Peptides
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mbl protein, Drosophila
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Glutamine
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polyglutamine
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RNA