Stem-cell based therapies for brain tumors

Curr Opin Mol Ther. 2008 Aug;10(4):334-42.


Advances in understanding neural stem cell (NSC) biology have facilitated the development of novel cell-based therapies for brain malignancies. NSCs are the most immature progenitor cells in the nervous system that have the ability to self-renew, differentiate into terminal neural cell types, and extensively migrate to areas of pathology in the central nervous system. Because of their inherent tumor-trophic properties and their capacity to differentiate into all neural phenotypes, NSCs represent a powerful tool for the treatment of both diffuse and localized neurological disorders. Progress has validated the feasibility of using engineered NSCs as cell-based therapeutic agents to eliminate malignant cells in the brain. This review discusses the therapeutic potential of NSCs focusing on brain tumors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain Neoplasms / therapy*
  • Cell- and Tissue-Based Therapy*
  • Humans
  • Neurons / physiology*
  • Stem Cell Transplantation*
  • Stem Cells / physiology