Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny

Bull Exp Biol Med. 2007 Nov;144(5):689-91. doi: 10.1007/s10517-007-0406-2.

Abstract

Effects of selank on learning, memory, and attention to sensory stimuli of different modality were studied in adult Wistar rats treated with 6-hydroxydopamine (neurotoxin selectively damaging catecholaminergic neurons and their terminals) during the first 3 days of life. Selank (300 microg/kg) restored cognitive processes disordered by chronic artificial inhibition of the cerebral catecholaminergic system.

MeSH terms

  • Animals
  • Animals, Newborn
  • Attention / drug effects
  • Behavior, Animal / drug effects*
  • Brain / drug effects
  • Brain / pathology
  • Brain / physiopathology
  • Catecholamines / metabolism*
  • Exploratory Behavior / drug effects
  • Hydroxydopamines / administration & dosage
  • Hydroxydopamines / toxicity
  • Injections, Intraperitoneal
  • Learning / drug effects
  • Male
  • Memory / drug effects
  • Neurons / drug effects*
  • Neurons / metabolism
  • Neurons / pathology
  • Neurotoxins / administration & dosage
  • Neurotoxins / toxicity
  • Oligopeptides / administration & dosage
  • Oligopeptides / pharmacology*
  • Rats
  • Rats, Wistar
  • Time Factors

Substances

  • Catecholamines
  • Hydroxydopamines
  • Neurotoxins
  • Oligopeptides
  • TP 7