Precursor lymphoblastic lymphoma reoccurring as a donor-derived neoplasm: a case report and review of the literature

Arch Pathol Lab Med. 2008 Aug;132(8):1342-5. doi: 10.5858/2008-132-1342-PLLRAA.


Precursor lymphoblastic lymphoma is an uncommon neoplasm. We report the case of a man who presented with precursor T lymphoblastic lymphoma and ultimately received an allogeneic bone marrow transplant from his human leukocyte antigen-identical sister. Four years later he developed recurrent disease. By means of DNA probing for the amelogenin locus and fluorescence in situ hybridization, the neoplastic cells of the recurrent lesion were found to be of donor origin. We offer the report of a patient with an unusual lymphoblastic lymphoma who, after successful bone marrow transplantation, developed the same disease of donor cell origin; further, we offer a literature review on donor cell lymphoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Amelogenin / genetics
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone Marrow Transplantation / adverse effects*
  • Chromosome Mapping
  • Fatal Outcome
  • Humans
  • In Situ Hybridization, Fluorescence
  • Kidney Neoplasms / etiology*
  • Kidney Neoplasms / genetics
  • Male
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / surgery*
  • Siblings
  • Testicular Neoplasms / drug therapy
  • Testicular Neoplasms / surgery*
  • Tissue Donors


  • Amelogenin