The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir

J Infect Dis. 2008 Sep 15;198(6):864-7. doi: 10.1086/591184.


The HLA-B 5701 allele is predictive of hypersensitivity reaction to abacavir, a response herein termed "ABC-HSR." This study of 1,103 individuals infected with human immunodeficiency virus assessed the usefulness of genotyping a HCP5 single-nucleotide polymorphism (SNP), rs2395029, in relation to ABC-HSR. In populations with European ancestry, rs2395029 is in linkage disequilibrium with HLA-B 5701. The HCP5 SNP was present in all 98 HLA-B 5701-positive individuals and was absent in 999 of 1005 HLA-B 5701-negative individuals. rs2395029 was overrepresented in 25 individuals with clinically likely ABC-HSR, compared with its frequency in 175 ABC-tolerant individuals (80% vs. 2%, respectively; P < .0001). Therefore, HCP5 genotyping could serve as a simple screening tool for ABC-HSR, particularly in settings where sequence-based HLA typing is not available.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / adverse effects*
  • Carrier State
  • Cohort Studies
  • Dideoxynucleosides / adverse effects*
  • Genotype
  • HLA-B Antigens / immunology
  • Humans
  • Hypersensitivity / immunology*
  • Major Histocompatibility Complex / genetics*
  • Polymorphism, Single Nucleotide*
  • Predictive Value of Tests
  • RNA, Long Noncoding
  • RNA, Untranslated


  • Anti-HIV Agents
  • Dideoxynucleosides
  • HCP5 long noncoding RNA, human
  • HLA-B Antigens
  • RNA, Long Noncoding
  • RNA, Untranslated
  • abacavir