Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease

Int J Chron Obstruct Pulmon Dis. 2008;3(2):253-68. doi: 10.2147/copd.s2089.


Since the early 1960s, a compelling body of evidence has accumulated to show that proteinases play critical roles in airspace enlargement in chronic obstructive pulmonary disease (COPD). However, until recently the causative enzymes and their exact roles in pathologic processes in COPD have not been clear. Recent studies of gene-targeted mice in murine models of COPD have confirmed roles for proteinases not only in airspace enlargement, but also in airway pathologies in COPD. These studies have also shed light on the specific proteinases involved in COPD pathogenesis, and the mechanisms by which these proteinases injure the lung. They have also identified important interactions between different classes of proteinases, and between proteinases and other molecules that amplify lung inflammation and injury. This review will discuss the biology of proteinases and the mechanisms by which they contribute to the pathogenesis of COPD. In addition, I will discuss the potential of proteinase inhibitors and anti-inflammatory drugs as new treatment strategies for COPD patients.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Disease Progression
  • Humans
  • Inflammation / enzymology
  • Inflammation / pathology
  • Peptide Hydrolases / metabolism*
  • Pulmonary Alveoli / enzymology
  • Pulmonary Alveoli / pathology
  • Pulmonary Disease, Chronic Obstructive* / drug therapy
  • Pulmonary Disease, Chronic Obstructive* / enzymology
  • Pulmonary Disease, Chronic Obstructive* / etiology
  • Serine Proteinase Inhibitors / therapeutic use


  • Serine Proteinase Inhibitors
  • Peptide Hydrolases