Etiopathogenesis of osteoarthritis

Rheum Dis Clin North Am. 2008 Aug;34(3):531-59. doi: 10.1016/j.rdc.2008.05.011.


In this article, the authors posit that, because osteoarthritis (OA) involves all of the tissues of the synovial joint, the emphasis on the loss of cartilage, in particular, is misguided. In contrast, the authors view OA as a process that is attempting to contain a mechanical problem in the joint. They argue that OA is best defined as failed repair of damage that has been caused by excessive mechanical stress on joint tissues. Because the body's innate mechanisms for repairing the damaged tissues cannot be effective in the face of the overwhelming mechanical abnormality, they cannot solve the problem of OA.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Biopsy, Needle
  • Cartilage, Articular / pathology
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry
  • Male
  • Osteoarthritis / complications
  • Osteoarthritis / etiology*
  • Osteoarthritis / pathology*
  • Osteoarthritis, Hip / complications
  • Osteoarthritis, Hip / etiology
  • Osteoarthritis, Hip / pathology
  • Osteoarthritis, Knee / complications
  • Osteoarthritis, Knee / etiology
  • Osteoarthritis, Knee / pathology
  • Pain / etiology*
  • Pain / physiopathology
  • Range of Motion, Articular / physiology
  • Risk Factors
  • Severity of Illness Index
  • Sex Factors
  • Stress, Mechanical
  • Synovial Membrane / pathology