Orthogonal ligation: a three piece assembly of a PNA-peptide-PNA conjugate

Chem Commun (Camb). 2008 Jun 28;(24):2785-7. doi: 10.1039/b801242c. Epub 2008 Apr 14.

Abstract

A PNA-peptide-PNA conjugate was assembled from three fragments using a combination of native chemical ligation and an orthogonal, auxiliary-mediated ligation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Chromatography, High Pressure Liquid
  • Models, Chemical
  • Molecular Sequence Data
  • Peptide Nucleic Acids / chemical synthesis*
  • Peptides / chemistry*
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Substances

  • Peptide Nucleic Acids
  • Peptides