Vitamin D and calcium interactions: functional outcomes

Am J Clin Nutr. 2008 Aug;88(2):541S-544S. doi: 10.1093/ajcn/88.2.541S.


I present the results of published studies and original data and describe the functional outcomes of effects related to the interaction between vitamin D status and calcium intake. These effects fall into 3 broad categories: 1) synergistic effects of vitamin D status and calcium intake on calcium absorption; 2) effects of calcium intake on vitamin D status; and 3) largely observational data suggesting an association between calcium and vitamin D status and nonskeletal outcomes, such as cancer. To a considerable extent, both vitamin D status and the benefits associated therewith appear to be dependent on, or at least augmented by, calcium intakes at or above currently recommended levels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bone Density Conservation Agents / metabolism*
  • Calcium / metabolism*
  • Calcium, Dietary / pharmacokinetics*
  • Drug Synergism
  • Humans
  • Intestinal Absorption / drug effects*
  • Intestinal Absorption / physiology
  • Vitamin D / metabolism*
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / prevention & control


  • Bone Density Conservation Agents
  • Calcium, Dietary
  • Vitamin D
  • Calcium