Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor

J Bacteriol. 2008 Oct;190(20):6903-8. doi: 10.1128/JB.00865-08. Epub 2008 Aug 8.

Abstract

The phosphopantetheinyl transferase genes SCO5883 (redU) and SCO6673 were disrupted in Streptomyces coelicolor. The redU mutants did not synthesize undecylprodigiosin, while SCO6673 mutants failed to produce calcium-dependent antibiotic. Neither gene was essential for actinorhodin production or morphological development in S. coelicolor, although their mutation could influence these processes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Anthraquinones / metabolism
  • Anti-Bacterial Agents / biosynthesis*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Benzoisochromanequinones
  • Gene Deletion
  • Mutagenesis, Insertional
  • Peptides / metabolism*
  • Prodigiosin / analogs & derivatives
  • Prodigiosin / biosynthesis
  • Streptomyces coelicolor / genetics
  • Streptomyces coelicolor / growth & development
  • Streptomyces coelicolor / metabolism*
  • Transferases (Other Substituted Phosphate Groups) / genetics
  • Transferases (Other Substituted Phosphate Groups) / metabolism*

Substances

  • Anthraquinones
  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Peptides
  • Prodigiosin
  • Transferases (Other Substituted Phosphate Groups)
  • CDA antibiotic
  • phosphopantetheinyl transferase
  • undecylprodigiosin
  • actinorhodin
  • Benzoisochromanequinones