Paerucumarin, a new metabolite produced by the pvc gene cluster from Pseudomonas aeruginosa

J Bacteriol. 2008 Oct;190(20):6927-30. doi: 10.1128/JB.00801-08. Epub 2008 Aug 8.


The pvc gene cluster from Pseudomonas aeruginosa has been linked to the biosynthesis of both the pyoverdine chromophore and pseudoverdine. Our reinvestigation of the role this gene cluster plays in P. aeruginosa secondary metabolite biosynthesis shows that its major product is actually paerucumarin, a novel isonitrile functionalized cumarin.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Coumarins / metabolism*
  • Genes, Bacterial
  • Mass Spectrometry
  • Metabolic Networks and Pathways / genetics
  • Multigene Family*
  • Oligopeptides / metabolism
  • Pseudomonas aeruginosa / genetics*
  • Pseudomonas aeruginosa / metabolism*
  • Umbelliferones / metabolism


  • Coumarins
  • Oligopeptides
  • Umbelliferones
  • pseudoverdin
  • pyoverdin