Different types of fatigue in patients with facioscapulohumeral dystrophy, myotonic dystrophy and HMSN-I. Experienced fatigue and physiological fatigue

Neurol Sci. 2008 Sep;29 Suppl 2:S238-40. doi: 10.1007/s10072-008-0949-7.

Abstract

Although fatigue is a common symptom in neuromuscular disorders, little is known about different types of fatigue. Sixty-five FSHD, 79 adult-onset MD and 73 HMSN type I patients were studied. Experienced fatigue was assessed with the CIS-fatigue subscale. Physiological fatigue was measured during a 2-min sustained maximal voluntary contraction of the biceps brachii muscle using the twitch interpolation technique to assess central activation failure (CAF) and peripheral fatigue. Experienced fatigue, CAF and peripheral fatigue appeared to be predominantly separate types of fatigue.

MeSH terms

  • Adult
  • Charcot-Marie-Tooth Disease / complications
  • Charcot-Marie-Tooth Disease / diagnosis
  • Charcot-Marie-Tooth Disease / physiopathology*
  • Disability Evaluation
  • Disease Progression
  • Exercise Test
  • Exercise Tolerance / physiology
  • Fatigue Syndrome, Chronic / diagnosis
  • Fatigue Syndrome, Chronic / etiology
  • Fatigue Syndrome, Chronic / physiopathology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscle Contraction / physiology
  • Muscle Fatigue / physiology
  • Muscle Weakness / diagnosis
  • Muscle Weakness / etiology
  • Muscle Weakness / physiopathology
  • Muscle, Skeletal / physiopathology
  • Muscular Dystrophy, Facioscapulohumeral / complications
  • Muscular Dystrophy, Facioscapulohumeral / diagnosis
  • Muscular Dystrophy, Facioscapulohumeral / physiopathology*
  • Myotonic Dystrophy / complications
  • Myotonic Dystrophy / diagnosis
  • Myotonic Dystrophy / physiopathology*
  • Neurologic Examination
  • Severity of Illness Index
  • Young Adult