Application of molecular tools for the diagnosis of central nervous system infections

Neurol Sci. 2008 Sep;29 Suppl 2(Suppl 2):S283-5. doi: 10.1007/s10072-008-0965-7.

Abstract

Many infectious agents can cause central nervous system (CNS) diseases in humans. Since microbial agents infecting CNS are numerous and have different features, conventional laboratory tests may not be sensitive enough to identify and characterise viruses and bacteria in human biological specimens. Thus, the need to define methods for the diagnosis of infectious neurological diseases, such as progressive multifocal leukoencephalopathy (PML), is urgent, in order to improve the outcome of the diseases with rapid and accurate detection of the pathogens.

Publication types

  • Review

MeSH terms

  • Central Nervous System Bacterial Infections / diagnosis*
  • Central Nervous System Infections / diagnosis*
  • Central Nervous System Infections / microbiology*
  • Central Nervous System Viral Diseases / diagnosis*
  • Cerebrospinal Fluid / microbiology
  • Clinical Laboratory Techniques / methods
  • Clinical Laboratory Techniques / standards
  • Clinical Laboratory Techniques / trends
  • Decision Trees
  • Diagnostic Techniques and Procedures / standards*
  • Diagnostic Techniques and Procedures / trends
  • Humans
  • Molecular Biology / methods*
  • Molecular Biology / standards*
  • Molecular Biology / trends